Efficacy of clade 2.3.2 H5 commercial vaccines in protecting chickens from clade 2.3.4.4 H5N8 highly pathogenic avian influenza infection.
Identifieur interne : 000067 ( Main/Exploration ); précédent : 000066; suivant : 000068Efficacy of clade 2.3.2 H5 commercial vaccines in protecting chickens from clade 2.3.4.4 H5N8 highly pathogenic avian influenza infection.
Auteurs : Seong-Su Yuk [Corée du Sud] ; T O Erdene-Ochir [Corée du Sud] ; Jung-Hoon Kwon [Corée du Sud] ; Jin-Yong Noh [Corée du Sud] ; Woo-Tack Hong [Corée du Sud] ; Jei-Hyun Jeong [Corée du Sud] ; Sol Jeong [Corée du Sud] ; Gyeong-Bin Gwon [Corée du Sud] ; Jong-Il Shin [Corée du Sud] ; Jung-Hyang Sur [Corée du Sud] ; Chang-Seon Song [Corée du Sud]Source :
- Vaccine [ 1873-2518 ] ; 2017.
Descripteurs français
- KwdFr :
- Allemagne (épidémiologie), Animaux (MeSH), Anticorps antiviraux (sang), Chine (épidémiologie), Efficacité du vaccin (MeSH), Excrétion virale (MeSH), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (mortalité), Grippe chez les oiseaux (prévention et contrôle), Grippe chez les oiseaux (épidémiologie), Italie (épidémiologie), Maladies de la volaille (immunologie), Maladies de la volaille (prévention et contrôle), Maladies de la volaille (virologie), Pays-Bas (épidémiologie), Poulets (MeSH), Royaume-Uni (épidémiologie), République de Corée (épidémiologie), Sous-type H5N1 du virus de la grippe A (immunologie), Sous-type H5N8 du virus de la grippe A (immunologie), Sous-type H5N8 du virus de la grippe A (pathogénicité), Tests d'inhibition de l'hémagglutination (MeSH), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Épidémies de maladies (médecine vétérinaire), Épidémies de maladies (prévention et contrôle).
- MESH :
- administration et posologie : Vaccins antigrippaux.
- effets indésirables : Vaccins antigrippaux.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Grippe chez les oiseaux, Maladies de la volaille, Sous-type H5N1 du virus de la grippe A, Sous-type H5N8 du virus de la grippe A, Vaccins antigrippaux.
- mortalité : Grippe chez les oiseaux.
- médecine vétérinaire : Épidémies de maladies.
- pathogénicité : Sous-type H5N8 du virus de la grippe A.
- prévention et contrôle : Grippe chez les oiseaux, Maladies de la volaille, Épidémies de maladies.
- sang : Anticorps antiviraux.
- virologie : Maladies de la volaille.
- épidémiologie : Allemagne, Chine, Grippe chez les oiseaux, Italie, Pays-Bas, Royaume-Uni, République de Corée.
- Animaux, Efficacité du vaccin, Excrétion virale, Poulets, Tests d'inhibition de l'hémagglutination.
English descriptors
- KwdEn :
- Animals (MeSH), Antibodies, Viral (blood), Chickens (MeSH), China (epidemiology), Disease Outbreaks (prevention & control), Disease Outbreaks (veterinary), Germany (epidemiology), Hemagglutination Inhibition Tests (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Influenza A Virus, H5N1 Subtype (immunology), Influenza A Virus, H5N8 Subtype (immunology), Influenza A Virus, H5N8 Subtype (pathogenicity), Influenza Vaccines (administration & dosage), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Influenza in Birds (epidemiology), Influenza in Birds (immunology), Influenza in Birds (mortality), Influenza in Birds (prevention & control), Italy (epidemiology), Netherlands (epidemiology), Poultry Diseases (immunology), Poultry Diseases (prevention & control), Poultry Diseases (virology), Republic of Korea (epidemiology), United Kingdom (epidemiology), Vaccine Potency (MeSH), Virus Shedding (MeSH).
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , adverse effects : Influenza Vaccines.
- chemical , blood : Antibodies, Viral.
- epidemiology : China, Germany, Influenza in Birds, Italy, Netherlands, Republic of Korea, United Kingdom.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza A Virus, H5N8 Subtype, Influenza Vaccines, Influenza in Birds, Poultry Diseases.
- mortality : Influenza in Birds.
- pathogenicity : Influenza A Virus, H5N8 Subtype.
- prevention & control : Disease Outbreaks, Influenza in Birds, Poultry Diseases.
- veterinary : Disease Outbreaks.
- virology : Poultry Diseases.
- Animals, Chickens, Hemagglutination Inhibition Tests, Vaccine Potency, Virus Shedding.
Abstract
Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.
DOI: 10.1016/j.vaccine.2017.01.033
PubMed: 28169074
Affiliations:
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Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sur, Jung Hyang" sort="Sur, Jung Hyang" uniqKey="Sur J" first="Jung-Hyang" last="Sur">Jung-Hyang Sur</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, 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uniqKey="Erdene Ochir T" first="T O" last="Erdene-Ochir">T O Erdene-Ochir</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kwon, Jung Hoon" sort="Kwon, Jung Hoon" uniqKey="Kwon J" first="Jung-Hoon" last="Kwon">Jung-Hoon Kwon</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Noh, Jin Yong" sort="Noh, Jin Yong" uniqKey="Noh J" first="Jin-Yong" last="Noh">Jin-Yong Noh</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Hong, Woo Tack" sort="Hong, Woo Tack" uniqKey="Hong W" first="Woo-Tack" last="Hong">Woo-Tack Hong</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Jei Hyun" sort="Jeong, Jei Hyun" uniqKey="Jeong J" first="Jei-Hyun" last="Jeong">Jei-Hyun Jeong</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Jeong, Sol" sort="Jeong, Sol" uniqKey="Jeong S" first="Sol" last="Jeong">Sol Jeong</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Gwon, Gyeong Bin" sort="Gwon, Gyeong Bin" uniqKey="Gwon G" first="Gyeong-Bin" last="Gwon">Gyeong-Bin Gwon</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Shin, Jong Il" sort="Shin, Jong Il" uniqKey="Shin J" first="Jong-Il" last="Shin">Jong-Il Shin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Sur, Jung Hyang" sort="Sur, Jung Hyang" uniqKey="Sur J" first="Jung-Hyang" last="Sur">Jung-Hyang Sur</name><affiliation wicri:level="1"><nlm:affiliation>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Song, Chang Seon" sort="Song, Chang Seon" uniqKey="Song C" first="Chang-Seon" last="Song">Chang-Seon Song</name><affiliation wicri:level="1"><nlm:affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address: songcs@konkuk.ac.kr.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="eISSN">1873-2518</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Antibodies, Viral (blood)</term><term>Chickens (MeSH)</term><term>China (epidemiology)</term><term>Disease Outbreaks (prevention & control)</term><term>Disease Outbreaks (veterinary)</term><term>Germany (epidemiology)</term><term>Hemagglutination Inhibition Tests (MeSH)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza A Virus, H5N8 Subtype (immunology)</term><term>Influenza A Virus, H5N8 Subtype (pathogenicity)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (adverse effects)</term><term>Influenza Vaccines (immunology)</term><term>Influenza in Birds (epidemiology)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (mortality)</term><term>Influenza in Birds (prevention & control)</term><term>Italy (epidemiology)</term><term>Netherlands (epidemiology)</term><term>Poultry Diseases (immunology)</term><term>Poultry Diseases (prevention & control)</term><term>Poultry Diseases (virology)</term><term>Republic of Korea (epidemiology)</term><term>United Kingdom (epidemiology)</term><term>Vaccine Potency (MeSH)</term><term>Virus Shedding (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Allemagne (épidémiologie)</term><term>Animaux (MeSH)</term><term>Anticorps antiviraux (sang)</term><term>Chine (épidémiologie)</term><term>Efficacité du vaccin (MeSH)</term><term>Excrétion virale (MeSH)</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe chez les oiseaux (mortalité)</term><term>Grippe chez les oiseaux (prévention et contrôle)</term><term>Grippe chez les oiseaux (épidémiologie)</term><term>Italie (épidémiologie)</term><term>Maladies de la volaille (immunologie)</term><term>Maladies de la volaille (prévention et contrôle)</term><term>Maladies de la volaille (virologie)</term><term>Pays-Bas (épidémiologie)</term><term>Poulets (MeSH)</term><term>Royaume-Uni (épidémiologie)</term><term>République de Corée (épidémiologie)</term><term>Sous-type H5N1 du virus de la grippe A (immunologie)</term><term>Sous-type H5N8 du virus de la grippe A (immunologie)</term><term>Sous-type H5N8 du virus de la grippe A (pathogénicité)</term><term>Tests d'inhibition de l'hémagglutination (MeSH)</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (effets indésirables)</term><term>Vaccins antigrippaux (immunologie)</term><term>Épidémies de maladies (médecine vétérinaire)</term><term>Épidémies de maladies (prévention et contrôle)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>China</term><term>Germany</term><term>Influenza in Birds</term><term>Italy</term><term>Netherlands</term><term>Republic of Korea</term><term>United Kingdom</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Sous-type H5N8 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza A Virus, H5N8 Subtype</term><term>Influenza Vaccines</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H5N8 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H5N8 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Disease Outbreaks</term><term>Influenza in Birds</term><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="prévention et contrôle" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Maladies de la volaille</term><term>Épidémies de maladies</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Disease Outbreaks</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Maladies de la volaille</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Poultry Diseases</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Chine</term><term>Grippe chez les oiseaux</term><term>Italie</term><term>Pays-Bas</term><term>Royaume-Uni</term><term>République de Corée</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chickens</term><term>Hemagglutination Inhibition Tests</term><term>Vaccine Potency</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Efficacité du vaccin</term><term>Excrétion virale</term><term>Poulets</term><term>Tests d'inhibition de l'hémagglutination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28169074</PMID><DateCompleted><Year>2017</Year><Month>12</Month><Day>15</Day></DateCompleted><DateRevised><Year>2018</Year><Month>02</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-2518</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>9</Issue><PubDate><Year>2017</Year><Month>03</Month><Day>01</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Efficacy of clade 2.3.2 H5 commercial vaccines in protecting chickens from clade 2.3.4.4 H5N8 highly pathogenic avian influenza infection.</ArticleTitle><Pagination><MedlinePgn>1316-1322</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0264-410X(17)30082-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.vaccine.2017.01.033</ELocationID><Abstract><AbstractText>Emerging clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) virus strain H5N8, which had been detected sporadically in domestic poultry in China, started to affect wild birds and poultry in South Korea in 2014. The virus was spread to Germany, Italy, the Netherlands, United Kingdom, and even United States by migratory birds. Here, we tested currently used commercial clade 2.3.2 H5 vaccines to evaluate mortality, clinical signs, virus shedding, and histological damage after experimental infection of chickens with the clade 2.3.4.4 HPAI H5N8 virus. Although the vaccination protected chickens from death, it failed to prevent chickens from shedding the virus and from tissue damage according to histological examination. These results suggest that the use of appropriate vaccines that match the currently epidemic HPAI virus is recommended, and continuous HPAI surveillance and testing of currently used commercial vaccines should be performed.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yuk</LastName><ForeName>Seong-Su</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erdene-Ochir</LastName><ForeName>T O</ForeName><Initials>TO</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kwon</LastName><ForeName>Jung-Hoon</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Noh</LastName><ForeName>Jin-Yong</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Woo-Tack</ForeName><Initials>WT</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Jei-Hyun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeong</LastName><ForeName>Sol</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gwon</LastName><ForeName>Gyeong-Bin</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shin</LastName><ForeName>Jong-Il</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sur</LastName><ForeName>Jung-Hyang</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Veterinary Pathology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Chang-Seon</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Avian Disease Laboratory, College of Veterinary Medicine, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address: songcs@konkuk.ac.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Vaccine</MedlineTA><NlmUniqueID>8406899</NlmUniqueID><ISSNLinking>0264-410X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002645" MajorTopicYN="N">Chickens</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName><QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006385" MajorTopicYN="N">Hemagglutination Inhibition Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053124" MajorTopicYN="N">Influenza A Virus, H5N1 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000071225" MajorTopicYN="N">Influenza A Virus, H5N8 Subtype</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" MajorTopicYN="N">Influenza in Birds</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007558" MajorTopicYN="N">Italy</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N">Netherlands</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011201" MajorTopicYN="N">Poultry Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056910" MajorTopicYN="N">Republic of Korea</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006113" MajorTopicYN="N">United Kingdom</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064166" MajorTopicYN="Y">Vaccine Potency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017201" MajorTopicYN="N">Virus Shedding</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Chicken</Keyword><Keyword MajorTopicYN="Y">H5N8</Keyword><Keyword MajorTopicYN="Y">Highly pathogenic avian influenza</Keyword><Keyword MajorTopicYN="Y">Vaccine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>10</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>12</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>01</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28169074</ArticleId><ArticleId IdType="pii">S0264-410X(17)30082-8</ArticleId><ArticleId IdType="doi">10.1016/j.vaccine.2017.01.033</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Yuk, Seong Su" sort="Yuk, Seong Su" uniqKey="Yuk S" first="Seong-Su" last="Yuk">Seong-Su Yuk</name></region><name sortKey="Erdene Ochir, T O" sort="Erdene Ochir, T O" uniqKey="Erdene Ochir T" first="T O" last="Erdene-Ochir">T O Erdene-Ochir</name><name sortKey="Gwon, Gyeong Bin" sort="Gwon, Gyeong Bin" uniqKey="Gwon G" first="Gyeong-Bin" last="Gwon">Gyeong-Bin Gwon</name><name sortKey="Hong, Woo Tack" sort="Hong, Woo Tack" uniqKey="Hong W" first="Woo-Tack" last="Hong">Woo-Tack Hong</name><name sortKey="Jeong, Jei Hyun" sort="Jeong, Jei Hyun" uniqKey="Jeong J" first="Jei-Hyun" last="Jeong">Jei-Hyun Jeong</name><name sortKey="Jeong, Sol" sort="Jeong, Sol" uniqKey="Jeong S" first="Sol" last="Jeong">Sol Jeong</name><name sortKey="Kwon, Jung Hoon" sort="Kwon, Jung Hoon" uniqKey="Kwon J" first="Jung-Hoon" last="Kwon">Jung-Hoon Kwon</name><name sortKey="Noh, Jin Yong" sort="Noh, Jin Yong" uniqKey="Noh J" first="Jin-Yong" last="Noh">Jin-Yong Noh</name><name sortKey="Shin, Jong Il" sort="Shin, Jong Il" uniqKey="Shin J" first="Jong-Il" last="Shin">Jong-Il Shin</name><name sortKey="Song, Chang Seon" sort="Song, Chang Seon" uniqKey="Song C" first="Chang-Seon" last="Song">Chang-Seon Song</name><name sortKey="Sur, Jung Hyang" sort="Sur, Jung Hyang" uniqKey="Sur J" first="Jung-Hyang" last="Sur">Jung-Hyang Sur</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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